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FWIW, she has cyclic vomiting syndrome with migraines from dysautonomia. For prophylactic administration zofran has better numbers. Zofran has safer side effect profile Ondansetron may be used for the prevention or treatment of nausea and vomiting but it may cause constipation or a headache. Zofran (ondansetron) works well to prevent nausea and vomiting. The reduction in anxiety was similar (ondansetron -13 mm, promethazine -14 mm; difference -1 mm; 95% CI = -10 to 10 mm) Any nausea med rec to take to my gi? Sedation is the main side effect. It's available in different forms that you don't have to swallow in case you can't keep anything down. Prescribed for Nausea/Vomiting, Nausea/Vomiting - Chemotherapy Induced more Prescription only Phenergan may be used to relieve allergy symptoms, nausea, or as a sleeping aid. Prescribed for Light Sedation, Allergic Reactions, Allergic Rhinitis, Anaphylaxis more Prescription only. No significant differences were seen in the blood pressures between groups (P > 0. There were more side-effects seen in the promethazine-treated when compared to the group with ondansetron treatment (P < 0. 6 / 5 average rating with 366 reviews forZofran. Zofran, phernegan, reglan (metoclopramide) & their relations=anaphylaxis. Ondansetron and promethazine are used to prevent nausea and vomiting. Zofran (ondansetron) Prescription only Phenergan (Promethazine) Prescription only Helps prevent nausea and vomiting. Heidi Fowler answered Psychiatry 26 years experience Drink it strong: Ginger can reduce nausea & upset stomach Nausea was reduced more significantly in the ondansetron-treated group (P < 0. Sedation is the main side effect Baseline nausea, anxiety, and sedation scores were similar. Comparing Phenergan vs Zofran Phenergan (promethazine) Zofran (ondansetron) Prescription only Phenergan may be used to relieve allergy symptoms, nausea, or as a sleeping aid. Brand names for promethazine include Phenergan, Phenadoz, and Promethegan. When should you not take Zofran? Brand names for ondansetron include Zofran, Zofran ODT, and Zuplenz. Phenergan (Promethazine) is used to treat and prevent nausea and vomiting from surgery, motion sickness, or pregnancy. Ondansetron and promethazine reduced nausea similarly (ondansetron -34 mm, promethazine -36 mm; difference -2 mm; 95% CI = -13 to 8 mm). Evidence shows that the outcome at 30 minutes after administration the outcome between zofran and phenergan are equal for relief of nausea. Promethazine is also used as an antihistamine and sedative.